Tyrosine kinase inhibitor起因有痛性筋痙攣にlevocarnitineが奏効した慢性骨髄性白血病

山田 充子; 黒田 裕行; 下山 紗央莉; 伊藤 亮; 須釜 佑介; 佐藤 健; 山内 夏未; 堀口 拓人; 中村 元; 濱口 孝太; 安部 智之; 藤井 重之; 前田 征洋; 加藤 淳二

doi:10.11406/rinketsu.57.489

Short Reports

Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia

Michiko YAMADA, Hiroyuki KURODA, Saori SHIMOYAMA, Ryo ITO, Yusuke SUGAMA, Ken SATO, Natsumi YAMAUCHI, Hiroto HORIGUCHI, Hajime NAKAMURA, Kota HAMAGUCHI, Tomoyuki ABE, Shigeyuki FUJII, Masahiro MAEDA, Junji KATO

Author information

Michiko YAMADA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Hiroyuki KURODA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Saori SHIMOYAMA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Dept. of Medical Oncology/Hematology, Internal Medicine, Sapporo Medical University
Ryo ITO
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Yusuke SUGAMA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Ken SATO
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Natsumi YAMAUCHI
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Hiroto HORIGUCHI
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Hajime NAKAMURA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Kota HAMAGUCHI
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Tomoyuki ABE
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Shigeyuki FUJII
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Masahiro MAEDA
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital
Junji KATO
Dept. of Medical Oncology/Hematology, Internal Medicine, Sapporo Medical University

Keywords: Carnitine, Muscle cramps, Tyrosine kinase inhibitor, Chronic myelogenous leukemia

JOURNAL RESTRICTED ACCESS

2016 Volume 57 Issue 4 Pages 489-491

DOI https://doi.org/10.11406/rinketsu.57.489

Details

Abstract

Muscle cramps are side effects commonly associated with tyrosine kinase inhibitor (TKI) treatment. Patients suffering from muscle cramps are treated with various medications such as calcium, magnesium and vitamin supplements, but these therapies are often ineffective. We report two patients with chronic myelogenous leukemia who developed muscle cramps caused by TKI. These patients were treated successfully with levocarnitine. Both of our cases revealed the beneficial effects of levocarnitine treatment on TKI-induced muscle cramps.

Corresponding author

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