Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Short Reports
A favorable clinical course of acute myeloid leukemia with t (6;21;8)(p23;q22;q22)
Atsushi WADA, Noriko DOKI, Yuki OTSUKA, Hiroto ADACHI, Ryosuke KONUMA, Yuya KISHIDA, Tatsuya KONISHI, Yuta YAMADA, Akihito NAGATA, Ryohei NAGATA, Atsushi MARUMO, Yuma NOGUCHI, Junichi MUKAE, Takashi TOYA, Aiko IGARASHI, Yuho NAJIMA, Takeshi KOBAYASHI, Hironori HARADA, Yuka HARADA, Hisashi SAKAMAKI, Kazuteru OHASHI
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Keywords: Acute myeloid leukemia, Three-way translocation, RUNX1/RUNX1T1
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2022 Volume 63 Issue 2 Pages 104-107

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Abstract

Variants of the t (8;21) (q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t (8;21) (q22;q22) in patients with acute myeloid leukemia (AML). However, the prognosis of AML with variant t (8;21) remains unknown due to the scarcity of reported cases. Herein we report a case of AML with t (6;21;8) (p23;q22;q22). Fluorescence in situ hybridization confirmed a RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8. This is the first report on a variant of t (8;21) involving the breakpoint 6p23. After induction chemotherapy, our patient achieved complete remission and has been stable for four years.

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© 2022 The Japanese Society of Hematology
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