Fibrinolytic Activity in Bone Marrow
1967 Volume 8 Issue 1 Pages 27-32
Details
1967 Volume 8 Issue 1 Pages 27-32
Experiment was done on 28 cases of blood diseases to determine tissue activator by the method of bone marrow puncture. The results were as follows.
Bone marrow smear was made by sternal aspiration 0.05 ml of the remaining blood was placed on fibrin plate and the tissue activator was determined after incubating for 4 hours at 37°C.
1) It was in the hemorrhagic diseases as aplastic anemia, thrombocytopenia, monocytic leukemia, myeloma, lymphosarcoma, etc. that the increase in activator was noticed with standard plate method.
In these blood diseases increase of plasmin was also observed when the bone marrow blood was applied to the heated plate.
2) Among the cases where the increase of plasmin and activator in the bone marrow blood was observed, there were some cases where the increase were not found in the venous blood.
3) There was no relation between nucleated cell count and fibrinolysis. Fibrinolysis increased when thrombocytes were below 5×104/mm3.
4) Fibrinolysis of bone marrow was inhibited by intravenous injection of t-AMCHA, antiplasmin agent.
