Abstract
A 15 year-old boy with congenital afibrinogenenmia was reported, and a review of 14 cases in Japan was made. Episodes of bleeding of this case began with umbilical bleeding and complicated with multiple bruises, nose bleeding and massive bleeding after teeth extractions, but no hematuria, melena, hematemesis, or spontaneous hemoarthralgia was seen.
General laboratory examinations revealed on specific abnormalities except for delayed sedimentation rate. Fibrinogen in the blood was not proved by the immunological method. Examination on clotting factors showed a complete absence of clotting due to absence on fibrinogen in the blood as well as remarkable decrease of fibrinolytic activity. The half of fibrinogen due to transfused Cohn Fraction I was 3.2 days. This seems to be the first case, in which the decreased fibrinolytic activity was found.
