Blood Platelet and Fibrinolysis

II. Effect of Fibrinolysis on Blood Platelet

Abstract

Effect of fibrinolysis on blood platelet was studied and following results were obtained.
1. Four groups of animals, such as normal dogs, thrombocytopenic dogs, normal rabbits and thrombocytopenic rabbits were kept in fibrinolytic state for one or two hours by intravenous injection of streptokinase. No remarkable changes in platelet counts were observed in any groups of animals.
2. Human platelet was incubated with plasmin and urokinase respectively for ten minutes. Fibrin clots were prepared mixing with normal untreated platelets, plasmin- or urokinase- treated platelets, and their lysis time were compared. Antifibrinolytic activity of platelets was suppressed by previous treatment with plasmin.
3. Lysing process of thin plasma clots prepared from platelet rich plasma of normal persons was observed with phasecontrast microscope and electron microscope. Platelets were deformed or destroyed under the hyperplasmic condition in which fibrin fibers were completely dissolved.