1968 Volume 9 Issue 4 Pages 552-559
A 34-year-old male with cholecystopathy and cryoglobulinemia was reported. Immunological examination revealed that the cryoglobulin of this patient is the “mixed type” consisting of IgG & IgM.
Rabbits were immunized with the purified cryoglobulin. The antiserum obtained reacted chiefly with IgG & IgM. Antigenic differences among the components of the cryoglobulin from this patient and of other three cryoglobulins of mixed type were not demonstrated using the antiserum.
Intracutaneous injection of the cryoglobulins failed to transfer the cold-hypersensitivity to normal recipients. Sera of four patients with cryoglobulinemia studied in our clinic were shown to have decreased or almost no complement-activity. But evidences were obtained that complements do not participate in cryoprecipitation. Effect by changing of the salt concentration on cryoprecipitation was also investigated.
