1993 Volume 7 Issue 2 Pages 110-118
ES-242-1, a novel bioxanthracene, is the first microbial compound found to act with a novel mechanism of action on the N-methyl-D-aspartate (NMDA) receptor and may possess neuroprotective properties useful in the treatment of disease involving glutamate toxicity. HS-142-1 is the first compound to be discovered as a specific antagonist for functional receptors for natriuretic peptide; the compound would be useful to clarify the physiological and pathophysiological functions of natriuretic peptides. The protein kinase inhibitor K-252a was recently reported to potentiate the activity of a neurotrophin and to promote some neuronal survival. K-252a and its derivatives would be lead compounds for the development of compounds therapeutically useful in the treatment of neurological disease and injury.
