2018 Volume 70 Issue 2 Pages 69-74
The aim of this study was to investigate clinical relevance of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H). The ASC-H patients diagnosed at our hospital were studied retrospectively; of 6644 conventional Pap smears, there were 204 specimens of ASC of undetermined significance (ASC-US) and 82 specimens of ASC-H. We have investigated the clinical results of the ASC-H patients. The ratio of ASC-H/ASC was 28.7%. We found hyperchromatic crowded cell groups as a cytological characteristic of ASC-H. Biopsies were performed for all ASC-H patients and revealed cervical intraepithelial neoplasia (CIN) 2/3 in 48.4% and negative results in 19.4%. The incidence of CIN2/3 was significantly higher in patients with ASC-H than in those with ASC-US. There was no significant difference in the histological results between premenopausal and postmenopausal patients with ASC-H. Among six patients with negative biopsies, one (16.7%)was diagnosed with CIN2 at 28 months later. ASC-H diagnosis is associated with a high incidence of CIN2/3. Patients whose biopsies are negative after an ASC-H interpretation still require close follow-up. [Adv Obstet Gynecol, 70 (2) : 69-74, 2018 (H30.5)]
