2020 Volume 72 Issue 2 Pages 96-101
We report three cases of a pregnant woman infected with syphilis exhibiting different clinical courses. In Case one, a 41-year-old woman was diagnosed as syphilis at eight weeks of gestation and treated with Amoxicillin. A healthy male baby was delivered at 38 weeks of gestation. In Case two, 22-year-old, a sex worker, who was absent of prenatal visit. She was diagnosed as intrauterine fetal death at the previous hospital. The exact week numbers in pregnancy was unknown. Case two presented with a substantial lesion suspicious of condyroma latum on the vulva and annular erythema on the face. RPR and TPHA were both positive, and the patient was diagnosed with syphilis infection. In Case three, a 28-year-old woman had an ultrasound abnormality detected at 36 weeks of gestation and was referred to our hospital. The fetus showed shortened femur length and polyhydramnios. She then delivered a female infant the next day. Further examination, the infant was diagnosed as congenital syphilis. The serology of Case three demonstrated negative RPR and TPHA in early pregnancy and positive after delivery. She was expected to be infected with syphilis during pregnancy. Immediate diagnosis and appropriate perinatal treatment is critical to prevent mother to infant infection. Furthermore, we should not hesitate to repeat serological tests for syphilis when pregnant women presented with suspicious finding of syphilis or ultrasound finding of intrauterine infection of syphilis, even if their serological tests were negative in early pregnancy.[Adv Obstet Gynecol, 72(2) : 96-101, 2020 (R2.5)]
