Comparative Study of Interupting Methods for Mid Trimester Pregnancy

Abstract

Three kinds of abortiva, quinine hydrochloride, prostaglandin E₂(PGE₂) and prostaglandin F_2α(PGF_2α) were used for interuption of mid trimester pregnancy, including 90 cases of elective abortion from 16 to 31 weeks pregnancy and 26 cases of missed abortion from 15 to 23 weeks pregnancy. Quinine hydrochloride and PGE₂ were orally and PGF_2α was extraanmiotically administered after pretreatment of cervical dilation with laminaria following by metroeulyner. The efficacy by different ways was compared by successful rate of abortion, mean time to abortion and mean amount of hemorrhage. The results obtained were as follows: 1. The mean time to complete abortion after administration of each medicine was 17.8±12.2 hours on quinine hydrochloride, 18.4±12.9 hours on PGE₂ and 10.5±11.2 hours on PGF_2α. 2. The mean amount of heamorrhage during abortion by each medicine was 228±207g on quinine hydrochloride, 122±102g for PGE₂ and 152±271g for PGF_2α. 3. The prrcentage of successful abortion within 36 hours after administration of each medicine was 88% in quinine chloride, 91% in PGE₂ and 100% in PGF_2α. 4. Mean dose of medicine for successful abortion was 0.69±0.004g on quinine hydrochloride, 6.4±5.5mg on PGE₂ and 4.5±2.3mg on PGF_2α. 5. The percentage of successful expell of placenta and mean time to deliver the placental tissue were no difference among those three groups.