Studies on the relationship between serum turbidity tests and immunoglobulin

with special reference to correlation with electrophoretic mobility

Abstract

1) Correlation between serum ZTT and TTT reaction and serum, γ-globulin has been noticed. It was demonstrated, however, that these reactions have higher correlation with the product of relative mobility and γ-globulin level.
2) It was suggested from the above results that contribution to the increase in serum ZTT and TTT reaction are stronger in γ-globulin with slower mobility than the faster one.
3) The suggestion was confirmed by experiment with IgG separated from normal human sera.
4) The above mentioned correlation was also observed in M-components of monoclonal gammopathies, especially in M-components composed of IgG.
5) It might be reasonable to assume that the M-component did not have the character of the so-called “paraprotein.”