Serum Lipoprotein Disc Electrophoretic Patterns and Ischemic Heart Disease

Abstract

Serum lipoprotein polyacryamide gel disc electrophoresis aided by paper electrophoresis was proved to be effective to detect and identify convincingly modest to moderate hyperlipoproteinemias which are frequently encountered in atherosclerotic cardiovascular clinic. Hyperbeta lipoproteinemia with moderate increase of pre-β lipoprotein (Bp pattern, type II-B of WHO definition) showed closest association with ischemic heart disease. Premature development of ischemic heart disease in the patients with this lipoprotein pattern was evident. Hyperbeta lipoproteinemia (B pattern, type II-A of WHO definition) showed also close association with high incidence and premature development of ischemic heart disease. Hyperprebeta lipoproteinemia (Pb pattern, type IV of WHO definition) occurred most frequently among atherosclerotic cardiovascular patients, though incidence of ischemic heart disease was lower than those with Bp or B patterns. The mixed hyperlipoproteinemia (PB pattern, the sixth phenotype) which is identifiable most adequately with PAG disc method showed the incidence of ischemic heart disease comparable to those in Pb pattern and the occurrence comparable to those in B pattern. The sixth phenotype should be the seventh phenotype because phenotype II-B (Bp pattern) is clearly differentiable from the mixed hyperlipoproteinemia (PB pattern).