An association of haptoglobin and α₁ antitrypsin phenotype with liver disease

Abstract

The phenotype of haptoglobin and α₁-antitrypsin was analyzed by polyacrylamide gel electrophoresis and isoelectric focusing on polyacrylamide gel in 100 healthy donors, 78 patients with chronic hepatitis and 83 patients with liver cirrhosis. The cirrhosis patients, especially the decompensated patients had an excess haptoglobin 1 gene and α₁-antitrypsin M3 gene. Statistical analysis revealed that the combined gene of haptoglobin 1 and α₁-antitrypsin M3 regulates the severity of chronic liver diseases resulting from chronic viral infection.