Abstract
In order to gain a bit more understanding of the effects of exercise on healthy subjects, we analysed urine samples obtained before and after strenous exercise. In the first group, consisting of 7 male students, the excretion of total protein, total alkaline phosphatase (ALP) and intestinal ALP (TAP) peaked, 1h after running 3km. Increases were also noted in high molecular mass ALP and IAP. From other group, made up of 20 male and 10 female high-schoolers, we examined samples of Tamm-Horsfall protein (THP) procured approximately 3h after the exercise regimen. It should be noted, here, that the subjects involved were all members of their school's track and field teams. Increases in the protein were seen in 4 of the males (3 of whom were jumpers, while the 4th was a middle long-distance runner) and in 1 of the females (also a middle long-distance runner). ALP and THP are GPI-anchor proteins. IAP and THP localize on the segment S 3 of the proximal tubule, and on the distal tubule of the kidney, respectively. Macromolecular ALP also increased after running. These findings may indicate that strenous exercises induce the intermittent renal injuries.
