Abstract
Serum PGAM activities and the percentage of brain-subunit activity against total activity (B/T) were determined in the cases of apoplexy and traumatic injury on head. PGAM activities already increased and peaked whthin 2h after the stroke. This findings were also recognized in the cases with head-trauma. They gradually decreased in 12h, 24h and 3 day after the attack. The grade and duration on the elevation of PGAM activities were more dominant in the serious cases than in the slight cases. In these cases with apoplexy and head-traum, B/T ratio almost remained in the normal range, namely about 90%. In the CSF, PGAM activities were consist of B-subunit, and significantly correlated with LD-activities and the protein content. In the experiment on SHRSP, serum PGAM activities were markedly increased during the stroke, compared with that of control rat. We suggest that serum PGAM activities would be an useful marker of apoplexy and the other brain damage.
