Abstract
The application of micromachining techniques to prepare microfabricated system for capillary electrophoresis is reviewed. Microstructures and capillaries, integrated detector systems, and integrated PCR micro-chamber are concepts that can be combined in a variety of ways to produce unique, miniaturized analytical systems for biomolecules. Microfabrication of 48 microchannels produces high throughput DNA analysis system. Integration of PCR and capillary electrophoresis was realized on a chip and allowed to amplification of DNA and fast analysis of the amplified fragments. Coupling of microfabricated capillary electrophoretic channels with mass spectrometer provides high throughput screening system for protein analysis, drug analysis, and DNA analysis.
