Genetic alterations in gastric preneoplastic lesions

in relation to H. pylori infection

Abstract

Helicobacter pylori (H. pylori) is now known as one of major factors to evoke gastroduodenal diseases including gastric carcinoma. In Japan, although more than 60 million people are reported to be H. pylori-positive, only less than 0.5% people suffers from gastric cancer. To know the real high risk group for the extention of preneoplastic change among H. pylori-positive cohorts, the information about the host genetic characteristics is one of the important clues. The present review summarizes the results of differences in host factors using animal model for H. pylori infection as well as human approach in the field of genetic polymorphism in relation to H. pylori infection.