Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin

Abstract

The aim of this study is to investigate the effect of isofraxidin, which is a major component of Acanthopanax senticosus Harms, on cell growth and the expression of genes encoding IL-1β, IL-6, MMP-1, and COX-2. For this purpose, a human synovial sarcoma cell line SW982 was used. Isofraxidin slightly inhibited the growth of SW982 cells at 450μM, but significantly suppressed the gene expression of IL-1β, IL-6, MMP-1, and COX-2 at 135μM as well as at 450μM. In addition, Isofraxidin supressed IL-6 production. These results suggest that isofraxidin exhibits anti-inflammatory effects.