How Can We Reduce the Discomfort of Malodors in the Nursing Care Scene? Development of Novel Fragrance Using Olfactory Receptor Technology

Abstract

Nursing care odor is a complex odor composed of strong malodors such as fecal and body odor. We have succeeded in developing novel deodorant fragrances for it that can significantly reduce discomfort by combining Olfactory Receptor (OR) and harmonizing technologies. Firstly, OR2L3 was found as the receptor to the fecal odor key components such as skatole and indole for the first time and then antagonists of it were discovered from fragrance materials. Next, to utilize the harmonizing technology that can change malodors into pleasant odors, we searched for essential oils that have a high harmonizing effect with the fecal odor by sensory evaluation. Finally, it was demonstrated that the combination of the technologies could greatly reduce the discomfort of the nursing care odor. Thus, it was verified that this complementary combination of the technologies could develop more effective deodorant fragrances for complex malodors. It can be expected that the deodorant fragrances developed in this study will relieve stress for both caregivers and care-receivers by reducing the discomfort of the nursing care odor, thereby it makes them healthier physically and mentally, leading to improvements in QOL.