Abstract
Perilla was evaluated an anti-allergy activity in vitro and the clinical examination.
TNF was used as the indicator.
TNF, which is a kind of monokine produced by macrophage, shows the anti-tumor activity. The activity induced by TNF is well known as one of BRM (Biological Response Modifiers) mechanism, however, the excessive production of TNF causes unfavorable inflammation.
Therefore, a suppressive activity of perilla on TNF production was examined.
When the perilla extract was applied to mice, TNF production decreased one-third compard with the placibo.
We added perilla extract to skin cream, and gave a clinical examination to allergodermia patients. The results were good for many of the patients.
