Abstract
The high-pressure homogenizer has been attracting attention for preparation of fine emulsion and liposome, etc. However, with the presently commercially available equipment, there are problems in such as 1) high energy is consumed because of highpressure, 2) preliminary emulsification is required, and 3) large-scale equipment is required even for laboratory use, resulting in difficulty to use. In order to resolve these problems, a high-performance liquid chromatograph system, which now has reached the maturity stage, is adopted for a pump system, and a new column type chamber which does not utilize cavitation is designed, thereby easily achieving the performance nearly equivalent to that of the existing high-prssure homogenizer without preliminary emulsification under the low pressure conditions. This chamber can be readily upscaled by utilizing the high-performance liquid chromatographic technique, and the use of this technique will enable the construction of a new flow emulsification systen with less dead volume, the level equivalent to that of the flow injection analysis of the chemical analysis technique.
