Abstract
Cosmetics and quasi-drugs will play new important roles in the aging and stressful society. We have proposed 3 clinical concepts, i.e., anti-drying, anti-UV radiation and anti-oxidation to prevent the skin aging. Especially, the importance of anti-oxidation is discussed in this paper. The results of the investigation of the peroxidation on skin surface using a CL-HPLC system, it was considered that ringlet oxygen was the key active oxygen on a human skin. We have clarified the reaction rate constants of the skin surface lipids and hypotaurine with singlet oxygen. And we have also confirmed that hypotaurine had a preventive effect against the peroxidation of squalene in a photo-oxidation system. Hypotaurine is known as a compound in a metabolism of sulfur containing amino acids and it exits in skin, eyeball, liver, brain, heart, serum and etc. And the “raison d'être” is also discussed in the living system for anti-oxidation. We propose that the re-structure and the reinforcement of the anti-oxidation mechanism in the living system will be the useful new concept in cosmetics.
