The Application of Thermosensitive Polymers to Liquid Plaster

Abstract

Liquid plasters, dissolved pyroxylin (nitrate ester of cellulose) in organic solvents, are classified as new quasi drugs or OTC drugs, which are used for the purpose of dressing damage and disinfection. The defects are the odor of the organic solvents, strong irritation against damaged skin, difficulty at the removal of formed film, and poor release of active ingredients from plasters. A thermosensitive polymer was prepared by copolymerization of N-isopropyl acrylamide and n-butyl methacrylate. The application of the thermosensitive polymer to liquid plaster improved the above defects, and showed formation of appropriate firm and effective antimicrobial activities.