A Case of Pleomorphic Adenoma and Ductal Carcinoma In Situ  in the Same Mammary Gland

Shiho Nagasawa; Koshi Matsui; Misato Araki; Emi Kanaya; Kohji Takagi; Ryo Muranushi; Yoshihiro Shirai; Toru Watanabe; Takeshi Miwa; Katsuhisa Hirano; Shinichi Sekine; Kazuto Shibuya; Isaya Hashimoto; Isaku Yoshioka; Kenichi Hirabayashi; Tsutomu Fujii

doi:10.70352/scrj.cr.24-0100

Case Report

A Case of Pleomorphic Adenoma and Ductal Carcinoma In Situ in the Same Mammary Gland

Shiho Nagasawa, Koshi Matsui , Misato Araki, Emi Kanaya, Kohji Takagi, Ryo Muranushi, Yoshihiro Shirai, Toru Watanabe, Takeshi Miwa, Katsuhisa Hirano, Shinichi Sekine, Kazuto Shibuya, Isaya Hashimoto, Isaku Yoshioka, Kenichi Hirabayashi, Tsutomu Fujii

Author information

Shiho Nagasawa
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Koshi Matsui Corresponding author
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Misato Araki
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Emi Kanaya
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Kohji Takagi
Department of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Ryo Muranushi
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Yoshihiro Shirai
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Toru Watanabe
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Takeshi Miwa
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Katsuhisa Hirano
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Shinichi Sekine
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Kazuto Shibuya
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Isaya Hashimoto
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Isaku Yoshioka
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Kenichi Hirabayashi
Department of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Tsutomu Fujii
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan

Keywords: pleomorphic adenoma, breast cancer, ductal carcinoma in situ, cartilaginous myxomatous stroma

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2025 Volume 11 Issue 1 Article ID: cr.24-0100

DOI https://doi.org/10.70352/scrj.cr.24-0100

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Abstract

INTRODUCTION: Pleomorphic adenoma is a benign tumor that frequently occurs in the salivary glands; however, it occurs in the breast rarely. There have been few reports of breast cancer complicated by pleomorphic adenoma of the mammary gland.

CASE PRESENTATION: A 70-year-old woman was found to have a mass lesion in her left breast during a medical examination. A needle biopsy was performed, and a diagnosis of pleomorphic adenoma was made. We performed a partial mastectomy with a margin of several millimeters from the tumor. Pathological examination revealed a diagnosis of pleomorphic adenoma with ductal carcinoma in situ. The resection margin was sufficient, and the patient was followed up.

CONCLUSIONS: Pleomorphic adenoma arising in the mammary gland is difficult to differentiate from adenomyoepithelioma, mucocele-like tumor, and metaplastic carcinoma. Since the tumor can become malignant, resection with a narrow margin is recommended, along with special efforts not to damage the capsule at diagnosis.

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