Control of Platelet Adhesion and Cell Attachment to He⁺ Ion Irradiated Collagen for the Development of Small Diameter Vascular Graft Material

Abstract

Our previous study indicated that He⁺-irradiated collagen grafts with a fluence of 1×10¹⁴ ions/cm² have excellent blood compatible properties. Also, the collagen grafts demonstrated a high antithrombogenicity and graft patency. 150 keV-He⁺ irradiated collagen with a fluence of 1×10¹⁴ ions/cm² simultaneously has the 2 properties of antithrombogenicity and cell attachment. In vitro platelet adhesion and plasma protein adsorption were evaluated to investigate the mechanisms of antithrombogenicity of these surfaces. Antithrombogenicity of the He⁺-irradiated collagen was caused by the reduction of the plasma protein adsorption such as the von Willebrand factor by ion beam irradiation.
He⁺-irradiated collagen surfaces will be useful for the substrates of small-diameter vascular grafts.