Abstract
Prazosin, a new α1-receptor blocking agent, was investigated for releasing and preventing effect on experimental cerebral vasospasm induced by oxyhemoglobin.
Four cats were treated by Prazosin before induction of vasospasm by oxyhemoglobin (pre-treatment group), and 6 cats were treated after (post-treatment group). In the pretreatment group, prevention of vasospasm was observed. In the post-treatment group induced vasospasm was released from 2 hours after administration of Prazosin.
The mechanism of preventing and releasing effect of Prazosin on cerebral vasospasm was discussed.
