Thrombolysis of Subarachnoid Clot using Tissue Plasminogen Activator

-The Development of Drug Delivery System using Biodegradable Polymer-

Abstract

A drug delivery system for fibrinolysis of the residual subarachnoid clot has been developed. Tissue plasminogen activator contained within the biodegradable polyer (polylactic acid) was more effective for the experimental clot lysis than was a placebo. In 3 patients with subarachnoid hemorrhage (WFNS Grade 3) TPA-PLA complex was administrated within the basal cistern after the aneurysmal neck clipping. The sequential changes of the concentration of FDP and of Hb in the cerebrospinal fluid drained through the cisternal drainage tube were monitored. The concentrations of both lowered more quickly in those patients treated with TPA-PLA complex than in those given a placebo. This DDS enables cisternal fibrinolytic therapy easily in comparison with the cisternal irrigation therapy, which requires careful observation of the water balance between irrigation and drainage.