1997 Volume 25 Issue 6 Pages 452-457
We studied the clinical and pathological aspects of 4 arteriovenous malformations (AVM) that were removed totally after preoperative embolization using poly (HEMA-co-MMA) or EVAL. Histopathological examination of AVM nidus embolized with poly (HEMA-co-MMA) showed mild inflammatory cell infiltrations in the vessel wall and small hemorrhages within the nidus and its surrounding brain tissue. On the other hand, EVAL-embolized AVM nidus demonstrated embolic materials within the vessels and inflammatory reaction of the vessel wall and its surrounding tissue, and patchy hemorrhages were also observed within the AVM nidus and its surrounding brain tissue. The difference of inflammatory response between two liquid embolic substances may reflect the difference of organic solvents. In conclusion, poly (HEMA-co-MMA) may be a superior embolic liquid for AVM before excision or radiosurgery because of less inflammatory response to AVM's vascular wall.
