Abstract
Efficient systems for catalytic asymmetric syntheses in aqueous media have been developed by using amphiphilic-resin-supported hydrophobic peptides having terminal prolyl groups. The supported peptide catalysts can be easily synthesized through the conventional solid-phase method, and have some merits such as reusability, applicability to sequential reactions, and facility for optimizing peptide sequences. The catalytic systems in aqueous media with the supported peptides are expected to provide the efficient procedures for the production of chiral fine chemicals.
