2023 Volume 75 Issue 2 Pages 119-121
In this study, to develop the room-temperature shipping of unstable liposomal drugs, we experimentally investigated the desiccation tolerance of Large Unilamellar Vesicle (LUV; φ200-300nm) which is the main component of liposomal drugs. LUVs loaded with trehalose or ε-poly-L-lysine(PLL) as dry protective agents was dispersed in the thin film of the protective agent solution. The film was vacuum-dried and rehydrated to measure the LUV diameter distribution. The diameter distribution of the LUV including PLL kept nearly the same dimeter distribution as that before the vacuum-drying. This suggests that LUV obtains desiccation tolerance by the addition of PLL.
