Extraction of 5-Hydroxymethylfurfural under Hydrogen Peroxide in Liquid–Liquid Slug Flow of Water / Methylisobutylketone Biphasic System and Effect of Hemin

Abstract

Continuous extraction process of 5-hydroxymethylfurfural (HMF) in the liquid-liquid slug flow of water/methyl isobutyl ketone (MIBK) formed in the microcapillary was examined under hydroperoxide (H₂O₂) as a reactive oxygen species (ROS). Addition of H₂O₂ reduced the extracted amount of HMF into the MIBK phase. However, the addition of hemin recovered the HMF extraction. This probably resulted from the competitive binding of H₂O₂ and HMF to hemin. The binding of hemin to H₂O₂ and HMF contributed to anti-ROS activity and an accelerated mass-transfer of HMF, respectively.