2007 Volume 50 Issue 3 Pages 344-349
Purpose: This study examined the relationship between tooth abnormalities and chemotherapy in children with neuroblastoma. Materials and methods: We performed oral examination and orthopantomography in 11 children(7 boys and 4 girls) before or after chemotherapy. They were diagnosed as having progressed neuroblastoma and were treated with chemotherapy in the pediatric department of a university hospital, Kyoto Prefectural University of Medicine. Results: As a result, chemotherapy was started between 2 months old and 5 years and 3 months old. In 7 patients that continued chemotherapy until they were 2 years old, tooth abnormalities were detected in the first premolar, second premolar, lateral incisor and second molar on orthopantomography examination. The tooth abnormalities occurred between the period of chemotherapy and tooth embryonic formation and calcification. Conclusion: We concluded that chemotherapy is associated with the formation of tooth germ defects.
