Cytotoxicities of Tooth Surface Modifying Agents

Abstract

We have considered that decreasing the surface free energy of the tooth surface may contribute to the prevention of caries and periodontal disease. We have successfully synthesized 1H, 1H, 2H, 2H-henicosafluorododecyltriisocyanatosilane (10F2S-3I) of the silane coupling agent having a fluorocarbon chain and two novel phosphate-type hybrid surfactants sodium 1-(4-heptadeca-fluorooctylphenyl) hexylphenylphosphate (FH5) and 1-[4-(perfluorooctyl)phenyl] hexylphosphate (F8H5P). Each modifier was effective in decreasing the surface free energy of the enamel surface. In this study, we investigated the cytotoxicities of these modifying agents. The cytotoxicities of various modified agents were evaluated according to 50% inhibitory concentration (IC₅₀). The IC₅₀ value of FH5 was 75%. The IC₅₀ values of F8H5P and 10F2S-3I showed more than 100% respectively. It suggested that FH5 has slight cytotoxicitiy, and F8H5P and 10F2S-3I have no cytotoxicities.