1990 Volume 53 Issue 4 Pages 361-373
Microvascular changes during microangiopathy in the diabetic rat retina and gingivae, especially the inner marginal epithelium of the gingiva, were investigated under TEM utilizing microvascular casts prepared by the plastic injection method. The endothelium of the retinal capillaries was also investigated under TEM.
The progress of microangiopathy in the retinal capillaries was examined 10 weeks after injection of streptozotocin. Microangiopathy in the inner marginal epithelium closed up rapidly 20 weeks after streptozotocin injection. This was accomapanied by microvasculature changes.
Investigation of the retinal vascular architecture due to microangiopathy was helpful in determining the severity of the diabetic condition.
