Physical properties and tissue response of canal sealer pastes containing tetracalcium phos-phate-chondroitin sulfate A

Abstract

We investigated the physical properties and tissue response to canal sealer pastes prepared of an equimolar mixture of tetracalcium phosphate and dicalcium phosphate dihydrate in McIlvaine's buffer solution containing 2.5 or 5.0% chondroitin sulfate A sodium salt. The pastes had a pH of about 8.5 immediately after kneading, their solubilities were 1.9 and 1.2%, respectively, and they displayed good sealing ability. Histologic examination revealed encapsulation and few inflammatory cells around the subcutaneously implanted pastes. Commercially available apatite sealer and zinc oxide eugenol sealer were encapsulated by thick fibrous tissue with many inflammatory cells. The prepared pastes promoted remineralization of alveolar bone in the periapical lesion better than commercially available sealers.