Change in the rate of formation of cerebrospinal fluid during deliberate hypotension induced with prostaglandin E_1 in anesthetized cats

Abstract

Although the effects of prostaglandin E_1 (PGE_1), a potent vasodilator on cerebral Vasculature have been reported, there have been no reports of its effects on cerebrospinal fluid (CSF) dynamics. I determined the rate of CSF formation (Vf), CSF pressure (CSFP), sagittal sinus pressure (SSP), carotid blood flow (CaBF), and regional cerebral blood flow (r-CBF) in anesthetized cats during and after decrease of arterial pressure induced by intravenous PGE_1. There were no significant changes in Vf, CSFP, or SSP during deliberate hypotension with PGE_1. Regardless of decreases in CaBF, r-CBF was maintained during hypotension. These findings indicated that PGE_1 does not significantly effect intracranial pressure dynamics, and therefore can be recommended for induction of deliberate hypotension under general anesthesia.