Effect of combined regional hyperthermia with injection of absolute ethanol into human oral carcinoma transplanted in nude mice

Abstract

We investigated the effect of combined regional hyperthermia with injection of absolute ethanol into human oral carcinoma (KB cells) transplanted subcutaneously in the leg of BALB/cA nude mice. Combined regional hyperthermia with injection of absolute ethanol seemed to have a potential inhibitory effect on the growth of the KB cells. In addition, the anti-tumor effect of hyperthermia with injection of 0.3ml/g absolute ethanol at 43℃ was nearly 5.8 fold that at 41℃ We concluded that combined regional hyperthermia with injection of absolute ethanol is an effective treatment.