Relationship between Clinicopathological Features and Prognosis for Patients with Primary Oral Squamous Cell Carcinoma

Abstract

Based on clinicopathologic features, we determined the prognosis of 117 patients with primary oral squamous cell carcinoma. Survival curves were prepared by the Kaplan-Meier method, and the relationship between the prognosis and clinicopathologic features of the disease was analysed using the generalized Wilcoxon method.
      The five-year cumulative survival rate of patients with poorly-differentiated carcinoma (by the WHO histological classification) was significantly lower than that of patients with well- or moderately-differentiated carcinoma. The survival rate of cases having a grade 4D mode of invasion (by the criteria of Yamamoto et al.) was also significantly less than that of other grades.
      These findings suggest it is necessary to reconsider treatment methods for patients with oral carcinoma that is poorly-differentiated or has a grade 4D mode of invasion.