Effects of drugs for heat sensitivity and thermotolerance on human oral carcinoma transplanted in nude mice

Abstract

I investigated the effects of Cepharanthin, Millisrol and Apresoline injected intraperitoneally for heat sensitivity and thermotolerance on human oral carcinoma (KB cells) transplanted subcutaneously in the leg of BALB/cA nude mice. The anti-tumor effect of hyperthermia with Cepharanthin, Millisrol and Apresoline was nearly 1.4, 1.6 and 1.8 fold that of hyperthermia alone. The volume of heat shock protein 70 was not diminished by injection of any of the drugs except Cepharanthin. I concluded that Millisrol and Apresoline are heat sensitization drugs, and that Cepharanthin is a heat sensitization and thermotolerance inhibition drug.