Administration of fibrinolysin and an antibiotic in periodontal pockets

Abstract

We evaluated the effect of administration of fibrinolysin (Elase ointment) and an antibiotic (Periocline^<<【○!R】>>) in periodontal pockets. Each patient received the following treatment: scaling alone at one site (group A), Elase^<【○!R】> administration four times at one week intervals at a second site (group B), Periocline^<【○!R】> administration four times at one week intervals at a third site (group C), and Elase^<【○!R】> administration four times at one week intervals in combination with Periocline^<【○!R】> at a fourth site (group D). Clinical and microbiological evaluations were performed before treatment as a baseline and one week after completion of treatment. All groups showed improvement over the baseline. Counts of viable organisms, anaerobes and black pigmented gram-negative anaerobic rods improved in all groups after treatment compared with the baseline.