Administration of fibrinolysin and an antibiotic in periodontal pockets

Abstract

In order to investigate the efficiency of minocycline (Periocline^®) and Periocline^® with DNase containing fibrinolysin (Elase^®) in periodontal pockets of adult periodontitis, I compared the periodontal index and bacterial changes of patients receiving no treatment (Group A, con-trols), those receiving Elase^® only (Group B), those receiving Periocline^® only (Group C) and those receiving Periocline^® with Elase^® (Group D). I also determined the minimum inhibitory con-centrations (MIC) of minocycline and minocycline with Elase^® against bacterial strains isolated from adult periodontitis. In all cases, the periodontal index of Group D was markedly better than that of Group C. Bacteriological examinations indicated that the total number of bacteria and ratio of anaerobic bacteria, especially black pigmented gram-negative anaerobic rods were less in Group D than Group C. Furthermore, the MIC of minocycline with Elase^® against the strains tested was lower than with alone. These results suggest that administration of Periocline^® with Elase^® in periodontal pockets of adults with periodontitis is more effective than administration of Periocline^® alone.