2000 Volume 63 Issue 2 Pages 167-
We examined the effect of clonidine with CFA (complete Freund's adjuvant) on neuritis in Sprague-Dawley rats us-ing behaviorassays. The animals were anesthetized and the common sciatic nerves were exposed bilaterally after in-traperitoneal injection of 50 μg / kg clonidine or saline. The left nerve was wrapped in a band of sterile hemostatic oxi-dized cellulose saturated with 50μL CFA. The right nerve was only exposed. Intraperitoneal injection of clonidine or saline were administered every 12 hours for a total of eight times. The response of the rats was checked 12 hours af-ter the last injection. We found that cold-allodynia and mechano-hyperalgesia, but not mechano-allodynia, were de-pressed in the rats that had received clonidine.
