2000 Volume 63 Issue 3 Pages 210-218
I carried out clinical, radiographic and histologic investigations on the effect of the induction therapy of simultaneous combination of external radiotherapy, chemotherapy using Bleomycin(BLM) or Peplomycin(PEP) and surgery for squamous cell carcinoma of the mandibular gingiva. The induction therapy generally included a total radiation dose of 30 Gy given in 15 fractions over 3 weeks together with intravenous injections of either a total BLM dose of 90 mg given in 6 fractions, or a total PEP dose of either 45 mg given in 9 fractions or 60 mg given in 6 fractions. This therapy seemed effective as a preoperative treatment for mandibular gingival carcinoma because it resulted in long-term remission of the tumor in many cases, even when used alone without adjunctive treatment. This effectiveness was confirmed in the histological examination of resected tissues. Precise preoperative imaging should be performed to determine the extent of tumor invasion in the mandible. When the mandibular canal has been invaded by the tumor, it must be excised to prevent tumor extension along the mandibular neurovascular bundle.
