2001 Volume 64 Issue 1 Pages 57-65
Nosocomial infection means infection acquired in medical facilities. As nosocomial infection is included among the opportunistic infection, immunocompromised host are infected easily. In the pathogen of nosocomial infection the resistant bacteria against various antibiotics and disinfectants cause nosocomial infection mostly, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and multidrug resistant Pseudomonas aeruginosa (MDRP). Resistance mechanism in MRSA and VRE are variation or alternation of antimicrobial targets. MRSA acquire resistance mechanism by production of penicillin-binding protein 2´ coded mec gene, and VRE acquire by aynthesis of _D-Alanyl^4-_DLactate^5 or _D-Alanyl^4-_D-Serine^5 coded van gene. MDRP show multidrug resistance by various resistance mechanism, that is production of inactivated enzyme, variation or alternation of antimicrobial targets, low outer membrane permeability, accelation of efflux systems and biofilm formation. The pathogen in nosocomial infection have a great variety of resistance mechanisms. In this symposium, I discuss nosocomial infection about MRSA, VRE and MDRP infection broke out even in dentistry and those resistance mechanisms.
