Expression of P-cadherin and cyclin D1 in oral squamous cell carcinomas
2002 Volume 65 Issue 1 Pages 1-10
Details
2002 Volume 65 Issue 1 Pages 1-10
In order to elucidate the adhesive function and potential for proliferation of carcinogenesis in oral cancer, we immunohistochemically investigated the expression of p-cadherin and cyclin D1 in oral epithelial hyperplasia, epithelial dysplasia and squamous cell carcinoma. The expression of P-cadherin was observed in the basal cell membrane, except in the cytomembrane facing the basal membrane, in normal epithelium and in epithelial hyperplasia. However, expression was not observed in the cytomembrane of the prickle cells or keratinized cells.
The expression was observed in the cytomembrane from the basal cell layer to the prickled cell layer in epithelial dysplasia, and in the cytomembrane of cancer cells from the peripheral region of the nest towards the center. However, the ctyomembranes were not positive for P-cadherin in the region facing the stroma or in the cancer pearls. On the other hand, the expression of cyclin D1 was observed scattered throughout the basal cells in the normal epithelium and in epithelial hyperplasia. Expression was seen in the cells from the basal cell layer to the prickle cell layer, and in all the cancer cells of the nests. There was significant difference between the expression of P-cadherin and the histological level of differentiation (P<0.01), but no difference between the expression of cyclin D1 and the histological level of differentiation. There was significant difference between the expression of P-cadherin and cyclin D1 (P=0.045). P-cadherin was overexpressed in cells that had a high potential of proliferation in epithelial dysplasia and in SCC accompanied by overexpression of cyclin D1.
Therefore, P-cadherin is responsible not only for cell adhesion but also for the potential of cell proliferation. In addition, the overexpression of P-cadherin and cyclin D1 might be associated with a high potential for cell proliferation through factors regulating the cell cycle. Shika Igaku (J Osaka Odontol Soc) 2002 Mar; 65(1): 1-10.
