Abstract

We investigated failure of the blood-nerve barrier (BNB) using a complete Freund's adjuvant (CFA) model, a Hashimoto model, an axotomy model, and a chronic constriction nerve injury (CCI) model. We also investigated whether thalidomide inhibited BNB failure. The CFA model did not show BNB failure, although the other three did. We found that administration of thalidomide to the CCI model inhibited failure of the BNB.