Histological study of gingival epithelium in a type n diabetes mellitus rat model

Abstract

It has been reported that more than 90% of diabetes mellitus (DM) patients in Japan suffer from the type II variety of the disease. Many studies have been conducted on the relationship between DM and periodontal disease. However, only a very few have focused on the morphological investigation of the epithelium in a type II diabetic rat model. We investigated and compared morphological changes in the gingival epithelium of both normal and type II diabetic rats. We found that development of the epithelium peg was very poor in the type n rats. We concluded that the epithelium of diabetic rats might be very weak to external stimuli.