Histological comparison of platelet-rich plasma and enamel matrix derivative on periodontal regeneration in rats

Abstract

We compared the histological effectiveness of treatment by platelet-rich plasma (PRP) and enamel matrix derivative (EMD) on rat periodontal defects. Palatal dehiscence defects were surgically created on the bilateral maxillary first molars. Both sides of the periodontal defects were filled with atelocollagen containing PRP (PRP group) or with atelocollagen containing EMD (EMD group). Five rats in each group were euthanized 2, 4 and 8 weeks after surgery. The results suggested that implanting PRP in periodontal defects significantly promoted bone regeneration. However, the effect of PRP on the formation of new cementum was inferior to that of EMD.