2 Effect of enamel matrix derivative on the implant-tissue interface

Abstract

We attempted to determine whether enamel matrix derivative (EMD) affects the quality of bone repair around titanium implants. Screw-shaped pure titanium implants were inserted in both tibia of beagle dogs with approximately 0.1mL of EMD gel. Removal torque strengths were measured at 3, 6, 9 and 12 weeks post-insertion. Higher removal torque strengths were achieved for the implants with EMD gel compared to the controls at 3, 6 and 9 weeks postinsertion. These results may indicate that EMD contributes to strengthening the interface between implant and bone, thus promoting the establishment of osseointegration at an earlier stage.