1 Effect of propofol on systemic vascular absorption of lidocaine after local infiltration anesthesia in rabbits

Abstract

We investigated the effect of propofol on the systemic vascular absorption of lidocaine after local infiltration anesthesia in rabbits. Propofol was administered intravenously to the animals which were divided into three groups: Group L, which received 2% lidocaine solution, Group LA-L, which received 2% lidocaine solution containing 1 : 160,000 adrenalin, and Group LA-H, which received 2% lidocaine solution containing 1 : 80,000 adrenalin. The plasma lidocaine concentration was determined after submucosal infiltration of the agent. The plasma lidocaine concentration in Group L was significantly greater than that in either the LA-L or LA-H group. The results suggest that intravenous propofol administration affects the absorption of lidocaine into the vascular system because the vasodilation induced by propofol decreases the vasoconstrictor effect of adrenalin.